9 PM Eye Drops (Latanoprost)
9 PM Eye Drops (Latanoprost) is a prostaglandin F2(alpha) analogue. Latanoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension by reducing intraocular pressure.Latanoprost is a prostanoid selective FP receptor agonist which is believed to reduce the intraocular pressure by increasing the outflow of aqueous humor. Studies in animals and man suggest that the main mechanism of action is increased uveoscleral outflow. Latanoprost Sterile Ophthalmic Solution is indicated for the reduction of elevated intraocular pressure in patients with open angle glaucoma and ocular hypertension.

Dosage 
The recommended dosage is one drop in the affected eye(s) once daily in the evening.

The dosage of Latanoprost Sterile Ophthalmic solution should not exceed once daily since it has been shown that more frequent administration may decrease the intraocular pressure lowering effect.

Reduction of the intraocular pressure starts approximately 3 to 4 hours after administration and the maximum effect is reached after 8 to 12 hours.

Latanoprost may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure. If more than one topical ophthalmic drug is being used, the drugs should be administered at least five (5) minutes apart.

Latanoprost Adverse Reactions / Latanoprost Side Effects

Brown pigmentation particularly in those with mixed-color irides; blepharitis, ocular irritation and pain; darkening, thickening and lengthening of eyelashes; localised oedema; conjunctival hyperaemia; transient punctate epithelial erosions; dyspnoea; exacerbation of asthma; local skin reactions; iritis; uveitis; darkening of palpebral skin.

Precautions

Special Risk Patients
Use caution in patients with active intraocular inflammation (eg, iritis, uveitis).

Eye pigmentation
Changes to pigmented tissue (eg, iris, periorbital tissue [eyelid], eyelashes) may occur.

Macular edema
Macular edema, including cystoid macular edema, may occur.

Special Precautions

Do not use within 5 minutes of thiomersal-containing preparations. Aphakia or pseudophakia with torn posterior lens cap or anterior chamber lenses; risk factors for cystoid macular oedema; brittle or severe asthma; history of intraocular inflammation; inflammatory, neovascular, angle-closure or congenital glaucoma; pregnancy, lactation. Remove contact lenses during use.