What is Fempro used for? Fempro tablets 2.5mg are used to treat breast cancer in postmenopausal women and are used as first line therapy for breast cancer that has been detected in an advanced or metastatic (spread outside the breast tissue) state. Fempro tablets 2.5mg are also used as additional or adjuvant treatment for early breast cancer in conjunction with other breast cancer treatment with tamoxifen, or if tamoxifen therapy has not helped prevent progression of the tumour. How does Fempro work? Fempro tablets 2.5mg contain letrozole, which is a potent and highly selective inhibitor of aromatase, an enzyme that is involved in the biosynthesis of the female hormone oestrogen. In premenopausal women the primary source of oestrogen production are the ovaries and it is involved in producing secondary sexual characteristics, such as breast development and in regulating the menstrual cycle. In postmenopausal women, when oestrogen production by the ovaries ceases, low levels of oestrogen are made in peripheral tissues, such as fat cells throughout the body, also some breast cancer cells, by conversion of androstenedione (produced by the adrenal glands) to estrone due to the action of aromatase and then by further conversion to oestradiol (the most active form of circulating oestrogen). Many breast cancers have oestrogen receptors and their growth is stimulated by oestrogen; low levels of oestrogen may be sufficient to maintain growth of breast cancer cells in women with breast cancer. Letrozole in Fempro tablets 2.5mg blocks the action of aromatase, preventing the formation of oestrogen and helping to prevent growth of oestrogen-dependent breast tumours. What does Fempro contain? Fempro tablets 2.5mg contain the active ingredient letrozole, an aromatase inhibitor that blocks oestrogen biosynthesis and is used to treat breast cancer. Treating breast cancer with Fempro Fempro tablets 2.5mg are used to treat breast cancer in postmenopausal women. They contain letrozole, which blocks the action of aromatase an enzyme involved in the biosynthesis of the female hormone oestrogen, in peripheral tissues, such as fat cells and also by some breast cancer cells. Many breast cancers have oestrogen receptors and their growth is stimulated by oestrogen; low levels of oestrogen may be sufficient to maintain growth of breast cancer cells in women with breast cancer. Letrozole in Fempro tablets 2.5mg blocks the action of aromatase, preventing the formation of oestrogen and helping to prevent growth of oestrogen-dependent breast tumours. Fempro tablets 2.5mg can be used as first-line therapy for advanced or metastatic (spread outside the breast tissue) breast cancer, also as adjuvant treatment in conjunction with other breast cancer drugs (tamoxifen) for early breast cancer; or if tamoxifen therapy has not helped prevent progression of the tumour. What are the side effects of Fempro? The most commonly reported side effects when taking Fempro tablets 2.5mg include, include: hot flushes, joint pain or stiffness, skin rash gastrointestinal upset (nausea, vomiting, diarrhoea), headache, dizziness, feeling weak (asthenia), vaginal dryness and bleeding, sleepiness, hair loss, anorexia, depression When should Fempro not be used? You should not use Fempro tablets 2.5mg if you: are allergic to letrozole or any ingredients in Fempro are premenopausal, pregnant or are breastfeeding have kidney or liver disease are taking medicines that interact with Fempro, including; oestrogen containing medication, tamoxifen, another breast cancer drug, without discussion with your doctor How should Fempro be taken? You should take your Fempro tablets 2.5mg with a glass of water once a day with or without food. You should continue taking your Fempro tablets 2.5mg for as long as recommended by your doctor, but in early cases of breast cancer, for no longer than 5 years. Femara is used in the treatment of breast cancers that require estrogen to grow and divide. It belongs to a class of drugs called aromatase inhibitors. Aromatase is an enzyme that is required for the production of estrogen in the body. Estrogen in turn is essential for the growth of hormone sensitive cancer cells. Hence the Femara drug essentially cuts off the supply of estrogen to these malignant cells and slows the progress of the disease. Precautions/Side Effects For Femara Since Femara or Letrozole lowers estrogen in the body, its treatment results in side effects associated with lowered estrogen levels. These include hot flashes, frequent sweating, stomach cramps and feeling of redness of the face. Many women also feel agitated and are prone to drastic mood swings. Fatigue and nausea are also common. These symptoms usually subside with progression of the treatment but if they don’t, additional efforts may be needed to treat them. Letrozole can cause fetal harm. Pregnant mothers are not prescribed these tablets as it can severely hamper fetal growth. Breast feeding mothers should discuss nurturing their infants with their doctors, as this drug can be passed into breast milk. Though there are no clear studies to establish the same, the risks should be debated. It is not advised to get pregnant during treatment with brand or generic Femara, and therefore, it is important that you use adequate contraception. The use of contraceptive pills must first be discussed, as those with hormone pills can cause adverse side effects. Any preexisting conditions of the liver or kidney may require dosage adjustment. Let your doctor know of any medication for these conditions. Many medications for cardiovascular problems are contraindicated. Femara Dosage The recommended dosage is 2.5mg per day taken for a period of about 5 years. This is the case if brand or generic Femara is used as adjuvant or extended treatment. In patients with first and second line treatment, the medication has to be continued till progression has stopped. If there is any evidence of relapse, the medication should be stopped and other modalities of treatment must begin. There is no need to adjust the dosage for treating individuals with mild hepatic impairment. However in patients with cirrhosis and severe hepatic impairment, the dosage is reduced to half. A 2.5 mg tablet is taken every other day.
PRECAUTIONS: Before taking letrozole, tell your doctor or pharmacist if you are allergic to it; or to anastrozole; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: high blood fats(cholesterol), bone problems (such as osteopenia, osteoporosis), stroke or blood clots, heart disease(such as chest pain, heart attack, heart failure), high blood pressure,
Femara 2.5 mg Tab(Letrozole)
- Product Code: PSAM012
- Availability: In Stock
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