Triomune (Lamivudine, Stavudine and Nevirapine Tablets) used
Triomune (Lamivudine, Stavudine and Nevirapine Tablets) is a fixed dose combination treatment for Human Immunodeficiency Virus (HIV) infection in adults. Triomune (Lamivudine, Stavudine and Nevirapine Tablets) are used to treat HIV patients who have already been treated with other HIV medications and have responded well to each of the drugs in the combination; and are also able to tolerate each of these medications, at the recommended doses without requiring a dose adjustment due to low weight. HIV impairs the immune system by attacking specific immune cells called CD4+ cells that are involved in fighting infection, which can lead to opportunistic life-threatening infection (infections that would not normally be harmful); also if too many CD4+ cells are destroyed this can result in acquired immune deficiency syndrome (AIDS). Triomune (Lamivudine, Stavudine and Nevirapine Tablets) prevent or slow down the ability of HIV to replicate and spread, which keeps the amount of virus (viral load) down to a low level; allowing the numbers of CD4+ cells to increase, so that the immune system can recover, reducing the risk of disease progression. Triple drug therapy with Triomune (Lamivudine, Stavudine and Nevirapine Tablets) makes it easier to take the medications regularly, which helps improve compliance and helps prevent resistance of HIV to individual drugs.
Triomune (Lamivudine, Stavudine and Nevirapine Tablets) work
Triomune (Lamivudine, Stavudine and Nevirapine Tablets) contain a combination of 3 antiretroviral drugs stavudine, lamivudine and nevirapine, which are effective only against RNA viruses (retroviruses) like Human Immunodeficiency Virus (HIV). These three drugs each work by inhibiting the action of the viral-specific enzyme reverse transcriptase (RT) which is needed for the virus to be able to replicate. Retroviruses convert RNA to DNA, which is then integrated into the DNA of infected immune cells so that the virus can replicate. Nevirapine in Triomune (Lamivudine, Stavudine and Nevirapine Tablets) is a dipyridodiazepine derivative non-nucleoside reverse transcriptase inhibitor (NNRTI); nucleosides are the precursors to the building blocks of DNA and RNA. Nevirapine in Triomune (Lamivudine, Stavudine and Nevirapine Tablets) acts by binding to a specific site on the RT enzyme, the enzyme's active site known as the NNRTI pocket, disrupting the catalytic site of the enzyme, and blocking its action in a manner that is noncompetitive with nucleosides. Stavudine and lamivudine are both nucleoside analogue reverse transcriptase inhibitors (NRTI), which means that they block the action of RT by competing with one of the nucleosides needed to transcribe the viral RNA into DNA, becoming incorporated into the chain of newly synthesized viral DNA and preventing it from growing (chain termination). Stavudine is an analogue of thymidine and lamivudine is an analogue of cytidine. The combined action of the three antiiretroviral drugs in Triomune (Lamivudine, Stavudine and Nevirapine Tablets) prevents the integration of the virus into the DNA of the infected CD4+ immune cell by 2 different mechanisms, which inhibits the replication of HIV so that no more virus can be produced and this reduces the viral load (amount of virus). Triomune (Lamivudine, Stavudine and Nevirapine Tablets) slows down the replication of HIV within your body but does not kill the virus already incorporated in the CD4+ cells or prevent the spread of the infection to others.
Use of antiretroviral agents like those found in Triomune can occasionally lead to fatal cases of lactic acidosis. Signs yo umay be developing lactic acisosis can include nausea, vomiting and abdominal pain, difficulty breathing, loss of appetite, weight loss, or muscle weakness. Tell your doctor if you notice any of these side effects while taking Triomune.
Other side effects reported with use of the individual active ingredients include:
- Stavudine: severe peripheral neuropathy (usually dose related, and more common in patients with advanced HIV infection or people who have previously experienced peripheral neuropathy
- Lamivudine: nausea, vomiting, headaches, abdominal pain and discomfort, peripheral neuropathy, arthralgias, myalgias, skin rash, pancreatitis
- Nevirapine: development of rash and liver toxicity (these can be potentially life-threatening so should be watched closely)
Do not take Triomune if you have ever had an allergic reaction to any of the active ingredients (stavudine / lamivudine / nevirapine).
Triomune must not be taken if you are pregnant or are breastfeeding.
Do not take Triomune if you have kidney or liver disease.
Triomune should only be taken if you have received previous treatment for HIV and specifically treatment with nevirapine.
have previously experienced peripheral neuropathy (damage to nerves in hands and feet causing tingling, numbness and pain)
Some medicines can interact negatively with Triomune. This may result in Triomune not working as intended, or Triomune can have a negative impact on the other medicines. Medicines that should not be taken with Triomune include:
- other antiretroviral agents (efavirenz, indinavir, lopinavir, nelfinavir, saquinavir, etc)
- oral contracepti
Triomune (Lamivudine, Stavudine and Nevirapine Tablets)
- Brands Cipla
- Product Code: PSHV026
- Availability: In Stock
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