Topamax (Topiramate Tablets) used
Topamax (Topiramate Tablets) are used to treat epilepsy in adults and children to control seizures, which happen when there is abnormal electrical activity in the brain. Topamax (Topiramate Tablets) are used as monotherapy (on its own) for adults and children (over 6) who have just been diagnosed with idiopathic epilepsy (of unknown cause) and who have either generalised tonic-clonic seizures, seizures affecting the whole brain (formerly known as grand mal seizures), which usually last 1-3 minutes; or partial seizures, which affect only part of the brain but can spread to the whole brain and these are called secondarily generalised seizures. Topamax (Topiramate Tablets) are also used in addition to another medication for controlling seizures in adults and children (over 2 years of age) in partial onset seizures, generalised tonic-clonic seizures but who have been unable to achieve control of seizures with other medications; also in children for treatment seizures associated with of Lennox-Gastaut syndrome, a form of childhood-onset epilepsy that causes frequent seizures and developmental problems. Topamax (Topiramate Tablets) are also used for the prevention of migraines in adults who have regular migraines (3 or more per month).
Topamax (Topiramate Tablets) work
Topamax (Topiramate Tablets) contain topiramate, an anticonvulsant used to treat epilepsy and control seizures. Nerve cells throughout the central nervous system communicate by sending out electrical signals, generated by the movement of electrically charged particles in and out of nerve cells, which travel to the all parts of the body via chemical messengers called neurotransmitters. This usually happens in an orderly fashion to control all our actions and thought processes. Epileptic seizures are thought to be caused by abnormal electrical activity in the brain, with uncontrolled, rapid and repetitive electrical signals being sent continually to various parts of the body, although the trigger for this abnormality is not known. Topiramate in Topamax (Topiramate Tablets) works directly on the brain cells to reduce the rate at which electrical signals are generated, calming the overactive nerve activity, by three different mechanisms. Conduction of electrical impulses is dependent on the flow of positive sodium ions into and out of the nerve cell through special sodium channels. Topiramate blocks these sodium channels and therefore reduces the neurone’s ability to send out continuous signals which cause seizures. Topiramate also has the ability to enhance the activity of gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter that regulates how much neurones can be excited (stimulated to send out electrical impulses), and inhibits the activity of the excitatory neurotransmitter glutamate, which adds to the calming effect on brain electrical activity. These three mechanisms are thought to contribute to the anticonvulsant activity of Topamax (Topiramate Tablets), which control seizures in epilepsy, but cannot cure them.
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