Pregabalin is active chemical substance of Lyrica, which is manufactured and sold by Pfizer Pharmaceuticals.Lyrica also used to treat fibromyalgia, anxiety disorders, peripheral neuropathic pain and treatment of partial epileptic seizures. Lyrica is an anti-convulsant (seizure) medicament and is used off-label by many doctors as a pain relief medication.

What are the possible side effects of pregabalin (Lyrica)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

muscle pain, weakness, or tenderness (especially if you also have a fever and feel tired);
vision problems;
easy bruising or bleeding; or
swelling in your hands or feet, rapid weight gain.
Less serious side effects may include:

dizziness, drowsiness;
loss of balance or coordination;
problems with memory or concentration;
breast swelling;
tremors; or
dry mouth, constipation.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about pregabalin (Lyrica)?

You may have thoughts about suicide while taking this medication. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, insomnia, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

If you are taking pregabalin to prevent seizures, keep taking the medication even if you feel fine.

Do not stop using pregabalin without first talking to your doctor, even if you feel fine. You may have increased seizures or withdrawal symptoms such as headache, sleep problems, nausea, and diarrhea. Ask your doctor how to avoid withdrawal symptoms when you stop using pregabalin.

Do not change your dose of pregabalin without your doctor's advice. Tell your doctor if the medication does not seem to work as well in treating your condition.