Diamox 250mg (Acetazolamide Tablets) used
Diamox 250mg (Acetazolamide Tablets) are used to treat a variety of conditions. These include conditions where there is a need to control fluid secretion, such as in some types of glaucoma; certain convulsive disorders, such as epilepsy and to help promote diuresis (removal of excess fluid by the kidneys) in conditions where there is abnormal fluid retention (oedema), such as congestive heart failure or in situations of drug-induced oedema. Diamox 250mg (Acetazolamide Tablets) is effective in treating these various conditions, working through the same mechanism to relieve associated symptoms.
Diamox 250mg (Acetazolamide Tablets) work
Diamox 250mg (Acetazolamide Tablets) contain acetazolamide, a potent inhibitor of the enzyme carbonic anhydrase that is found in several tissues in the body and catalyzes the rapid conversion of carbon dioxide to bicarbonate ions, to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues. In the eye, the formation of aqueous humour or eye fluid, is dependent on carbonic anhydrase to filter fluid out of the capillaries (small blood vessels) into the eye. acetazolamide in Diamox 250mg (Acetazolamide Tablets) Inhibits carbonic anhydrase in the eye and this interferes with the formation of bicarbonate ions and ultimately with the filtration process, which decreases secretion of aqueous humour into the eye. The result is a reduction in intraocular pressure (IOP) which relieves pressure on the optic nerve and helps prevent loss of sight due to increased IOP associated with glaucoma. In the central nervous system, acetazolamide in Diamox 250mg (Acetazolamide Tablets) inhibits carbonic anhydrase in nerve cells or neurons, which can help control abnormal, paroxysmal (short frequent), excessive discharge (transmission of signal between nerve cells) from neurons that can cause convulsion such as in epilepsy. Acetazolamide in Diamox 250mg (Acetazolamide Tablets) also has a diuretic effect, which is due to its inhibition of carbonic anhydrase in the proximal tubules of the kidney. This action decreases concentration of hydrogen ion in the renal tubules, and increases excretion of sodium, potassium, bicarbonate, and water, helping to remove excess water from tissues that can happen as a result of certain conditions like congestive heart failure.
What are the side effects of Diamox, Diamox Sequels (acetazolamide)?
Common side effects include:
- Paresthesias (tingling, numbness, burning, prickling)
- Ringing in the ears
- Hearing problems
- Loss of appetite
- Changes in taste
- Frequent urination
Other less common side effects include:
- Transient myopia
- Sensitivity to light
- Glucose in the urine
- Blood in urine
- Pain at injection site
Possible serious side effects of Diamox:
Possible serious side effects include:
- Liver problems
- Flaccid paralysis
- Stevens-Johnson syndrome (severe skin rash)
- Toxic epidermal necrolysis (severe skin rash)
- Agranulocytosis (decrease in white blood cells)
- Aplastic anemia and other blood disorders
- Metabolic acidosis
- Electrolyte imbalance
- Growth retardation in children
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