Cozaar (Losartan Tablets) used
Cozaar (Losartan Tablets) are used to treat hypertension, which is high blood pressure when at rest; particularly if you have left ventricular hypertrophy, which is when the heart works harder due to high blood pressure, causing thickening of the left pumping chamber of the heart. Although there are usually no other symptoms, high blood pressure increases risk of cardiovascular disease and Cozaar (Losartan Tablets) reduce the risk of stroke and heart attack, by lowering blood pressure to normal resting levels. This helps the heart to cope better, reducing symptoms of breathlessness on exertion and also increasing life expectancy. Cozaar (Losartan Tablets) are also used to treat patients with heart failure, which is when the heart muscles are weakened and cannot pump efficiently; and patients who have had a heart attack, to improve survival and prevent further damage to the heart. Cozaar (Losartan Tablets) are also used to help prevent the progression of kidney disease in people with type-2 diabetes in which the kidneys are severely damaged and there is protein in the urine, this reduces the need for dialysis or transplantation.
Cozaar (Losartan Tablets) work
Cozaar (Losartan Tablets) contain losartan, an angiotensin II receptor blocker (ARB), which acts by blocking the binding of the hormone angiotensin II to its receptor in a variety of tissues including vascular smooth muscle (blood vessel walls) and kidney cells. Angiotensin II is a naturally produced hormone that has several actions involved in regulating blood pressure, which is the force needed to pump blood around the body; as well as regulating fluid balance, the amount of water removed from the blood by the kidneys. Angiotensin II causes salt (sodium and potassium) and water retention by the kidneys, and causes blood vessels to constrict (narrow); this increases blood volume while at the same time reducing blood vessel volume, which increases blood pressure. Losartan in Cozaar (Losartan Tablets) blocks the binding of Angiotensin II to its receptor, preventing its pressor actions (blood pressure increasing) resulting in dilation (widening) of blood vessel and increased amount of salt and water removed by the kidneys into the urine, which lowers blood pressure. Reducing blood pressure reduces the workload on the heart and reduces risk of cardiovascular disease; as well as helping to damaged kidneys work more efficiently to reduce loss of protein into the urine.
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