Moduretic (Amiloride and Hydrochlorothiazide Tablets) used 

Moduretic (Amiloride and Hydrochlorothiazide Tablets) are used to help lower blood pressure in the treatment of hypertension, which is high blood pressure when at rest, particularly if there is risk of depletion of potassium from the blood. They can used be either alone or in combination with other antihypertensive medication. Moduretic (Amiloride and Hydrochlorothiazide Tablets) are also used to treat oedema (water retention) caused by several conditions, including oedema associated with congestive heart failure; hepatic cirrhosis with ascites, which is liver disease that causes accumulation of fluid in the abdominal cavity. Moduretic (Amiloride and Hydrochlorothiazide Tablets) help remove excess fluid from the body tissues, such as around the feet and ankles, which can become very swollen, and also from the blood and for this reason they are often called water tablets.

Moduretic (Amiloride and Hydrochlorothiazide Tablets) work

Moduretic (Amiloride and Hydrochlorothiazide Tablets) contain a combination of two drugs, amiloride hydrochloride and hydrochlorothiazide, which are both diuretic and antihypertensive medications. Amiloride hydrochloride in Moduretic (Amiloride and Hydrochlorothiazide Tablets) is a weak diuretic that is also potassium sparing and acts by blocking the sodium channels in the kidney cells at the distal convoluted tubule, cortical collecting tubule and collecting duct. This action inhibits reabsorption of sodium and chloride ions back into the blood resulting in loss of sodium and water without loss of potassium. Hydrochlorothiazide in Moduretic (Amiloride and Hydrochlorothiazide Tablets) is a thiazide diuretic that acts directly on the distal convoluted tubule of the kidneys. This action inhibits the renal tubular reabsorption of sodium and chloride ions back into the blood, and promotes their excretion along with water. The combined action of amiloride hydrochloride and hydrochlorothiazide in Moduretic (Amiloride and Hydrochlorothiazide Tablets) increases the urine volume and decreases blood volume, which removes excess fluid caused by oedema and reduces blood pressure. Moduretic (Amiloride and Hydrochlorothiazide Tablets) begins to work within 1-2 hours and its effect lasts up to 24 hours.